Christopher Pittenger Selected Research

Tourette Syndrome (Tourette's Syndrome)

4/2024	Activation of M4 muscarinic receptors in the striatum reduces tic-like behaviours in two distinct murine models of Tourette syndrome.
1/2022	White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology.
1/2020	The histidine decarboxylase model of tic pathophysiology: a new focus on the histamine H3 receptor.
1/2017	Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions.
1/2017	Histamine modulation of the basal ganglia circuitry in the development of pathological grooming.
1/2016	Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions.
5/2015	Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear.
1/2015	Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome.
1/2014	Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice.

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Christopher Pittenger Research Topics

Disease

26	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 01/2024 - 09/2005
9	Tourette Syndrome (Tourette's Syndrome) 04/2024 - 01/2014
9	Tics (Tic) 04/2024 - 01/2014
5	Mental Disorders (Mental Disorder) 01/2023 - 01/2005
4	Tic Disorders (Tic Disorder) 07/2023 - 01/2016
3	Bipolar Disorder (Manic Depressive Psychosis) 01/2023 - 01/2008
3	Schizophrenia (Dementia Praecox) 01/2023 - 01/2016
3	Major Depressive Disorder (Major Depressive Disorders) 01/2022 - 04/2007
3	Trichotillomania 03/2013 - 01/2007
2	Neuroinflammatory Diseases 01/2023 - 01/2023
2	Parkinson Disease (Parkinson's Disease) 01/2023 - 01/2019
2	Inflammation (Inflammations) 10/2016 - 06/2008
2	Anxiety Disorders (Anxiety Disorder) 06/2011 - 01/2008
2	Alzheimer Disease (Alzheimer's Disease) 11/2010 - 06/2008
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2008 - 01/2006
1	Antisocial Personality Disorder (Antisocial Personality) 12/2023
1	Hemoglobin SC Disease (Disease, Hemoglobin SC) 01/2023
1	Infections 01/2023
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2022
1	Neurodevelopmental Disorders 01/2021
1	Telomeric 22q13 Monosomy Syndrome 01/2021
1	Autism Spectrum Disorder 01/2021
1	Dyskinesias (Dyskinesia) 01/2019
1	Alcoholism (Alcohol Abuse) 01/2017
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2016
1	Narcolepsy 01/2016
1	Disorders of Excessive Somnolence (Hypersomnia) 01/2016
1	Nausea 08/2015
1	Seizures (Absence Seizure) 03/2015
1	Respiratory Insufficiency (Respiratory Failure) 07/2013
1	Mood Disorders (Mood Disorder) 06/2011
1	Dementia (Dementias) 06/2008
1	Alcohol Withdrawal Delirium (Delirium Tremens) 03/2007
1	Excoriation Disorder 12/2006
1	Hallucinations (Hallucination) 04/2006
1	Borderline Personality Disorder (Personality Disorders, Borderline) 11/2005

Drug/Important Bio-Agent (IBA)

9	Glutamic Acid (Glutamate)FDA Link 07/2017 - 11/2005
8	Riluzole FDA LinkGeneric 08/2015 - 09/2005
7	Histidine DecarboxylaseIBA 01/2022 - 01/2014
6	Histamine (Histamine Dihydrochloride)FDA Link 01/2020 - 01/2016
5	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2022 - 01/2006
4	Psilocybin (Psilocibin)IBA 01/2024 - 12/2022
3	Cholinergic Agents (Cholinergics)IBA 07/2023 - 01/2015
3	Acetylcysteine (Siran)FDA LinkGeneric 07/2017 - 01/2006
3	Ketamine FDA LinkGeneric 01/2017 - 12/2012
2	Haloperidol (Haldol)FDA LinkGeneric 07/2023 - 01/2014
2	Hallucinogens (Psychedelics)IBA 01/2023 - 01/2022
2	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2023
2	Antidepressive Agents (Antidepressants)IBA 01/2022 - 07/2013
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2008
2	Histamine Receptors (Histamine Receptor)IBA 11/2018 - 01/2016
2	EnzymesIBA 01/2017 - 01/2017
2	Dextroamphetamine (Dexedrine)FDA LinkGeneric 05/2015 - 01/2015
2	Dopamine (Intropin)FDA LinkGeneric 01/2014 - 06/2011
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 07/2013 - 04/2007
1	Muscarinic M4 ReceptorIBA 04/2024
1	Acetylcholine (Acetylcholine Chloride)FDA Link 04/2024
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 04/2024
1	xanomelineIBA 04/2024
1	AutoantibodiesIBA 01/2023
1	NeurosteroidsIBA 01/2023
1	Pregnanolone (Allopregnanolone)IBA 01/2023
1	Messenger RNA (mRNA)IBA 01/2023
1	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 01/2022
1	methyloneIBA 01/2022
1	Histamine H3 Receptors (Histamine H3 Receptor)IBA 01/2020
1	Levodopa (L Dopa)FDA LinkGeneric 01/2019
1	AntioxidantsIBA 07/2017
1	Nonsense Codon (Nonsense Mutation)IBA 01/2017
1	Pharmacologic ActionsIBA 01/2016
1	pitolisantIBA 01/2016
1	PicrotoxinIBA 03/2015
1	GABA-A Receptors (GABA(A) Receptor)IBA 03/2015
1	MuscimolIBA 03/2015
1	Dopamine Agents (Dopaminergic Agents)IBA 01/2015
1	Hypnotics and Sedatives (Sedatives)IBA 07/2013
1	GoldIBA 06/2011
1	IGF-I-IGFBP-3 complex FDA Link 06/2011
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2010
1	Tyrosine (L-Tyrosine)FDA Link 11/2010
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 09/2008
1	Transforming Growth Factors (Transforming Growth Factor)IBA 06/2008
1	Amyloid (Amyloid Fibrils)IBA 06/2008
1	CytokinesIBA 06/2008
1	Transforming Growth Factor beta (TGF-beta)IBA 06/2008
1	Amyloid beta-PeptidesIBA 06/2008
1	Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA 06/2008
1	Amino Acids FDA Link 01/2008
1	Clomipramine (Anafranil)FDA LinkGeneric 10/2007
1	Gabapentin (Neurontin)FDA LinkGeneric 03/2007
1	Bupropion (Wellbutrin)FDA LinkGeneric 04/2006
1	Memantine (Namenda)FDA Link 04/2006

Therapy/Procedure

9	Therapeutics 07/2023 - 09/2005
7	Drug Therapy (Chemotherapy) 04/2024 - 01/2005
2	Neurofeedback 10/2023 - 01/2014
2	Transcranial Direct Current Stimulation 01/2022 - 11/2021
1	Anesthesia 07/2013
1	Off-Label Use 07/2013